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An innovative formulation designed to be liquid from inception to injection1. Ready-to-use and no need to reconstitute, Alluzience (Botulinum toxin type A) is engineered for precision and performance.1,2
Alluzience is indicated for the temporary improvement in the appearance of moderate to severe glabellar lines (vertical lines between eyebrows) seen at a maximum frown in adult patients under 65 years, when the severity of these lines has an important psychological impact on the patient.1


Designed to be liquid from inception to injection1

No human or animal-derived exipients1

Could help to reduce preparation time and treatment waste1,3

Improved patients’ psychological well-being on the SmPC1


Rapid onset of effect, seen as early as 24 hours1,2

Long duration up to 6 months1,2

No reconstitution required, ready-to-use1

Precise dosing for replicable results over multiple treatment cycles1,2

*[ABO 24% (n=250) Vs placebo 4% (n=122)]
**595 patients received up to 5 treatment cycles over 12 months in a long term open-label phase 3 study and by investigator assessment efficacy was
maintained over the 12 months.1
Post hoc analysis of pooled Phase 3 data from Studies 189 and 214. The efficacy was assessed by pooled outcome of two placebo controlled, randomised clinical trials. The primary endpoint was Investigator Live Assessment (ILA) responder rate at day 29. Alluzience (n=250) ILA day 29: 87.6%.
Placebo (n=122) ILA day 29: 2.5% p<0.0001
†† Data from study 214. Response was defined as having severity grading of glabellar lines as ‘none or mild’ at maximum frown.
Note 1: Not included in Summary of Product Characteristics.
Note 2: Responders were defined as having a glabellar line severity grade of ‘none or mild’ and calculated based on the modified intention-to-treat
population for pooled Studies 189 and 214.
Note 3: Response to onset was defined as ‘Yes’ in response to ‘Since being injected have you noticed an improvement in the appearance of your
glabellar lines (lines between your eyebrows)?’ for the modified intention-to-treat population. Assessed using subject diary cards.
ABO, botulinum toxin type-A; ILA, Investigator’s Live Assessment.


Proven treatment satisfaction in 85% of patients at 1 month1,3* [Note 1]

[85% (n=250), vs Placebo, 9% (n=122) p<0.0001]


Clinically proven uplift to psychological

Alluzience provides significant improvements in patient happiness and confidence based on the FACE-Q3© scales1*[Note 2]
[Week 1 to month 3: p<0.001 vs placebo, months 4 and
5: p<0.01 vs placebo and month 6: p<0.05 vs placebo.
Alluzience (n=250), Placebo (n=122)]

* Pooled Phase 3 data from Studies 189 and 214.
Note 1: Patients who were satisfied or very satisfied with the appearance of their glabellar lines among those with a rating of dissatisfied or very dissatisfied at baseline.
Note 2: As assessed by patients themselves

A majority of adverse reactions re.ported with Alluzience in clinical trials were of mild to moderate intensity and reversible.1
The most frequently reported adverse reactions were headache and injection site reactions.1
The incidence of adverse reactions tended to decrease with repeated treatments.1

Contraindications include hypersensitivity to the active substance or to any of the excipients, presence of infection at the proposed injection sites and presence of myasthenia gravis, Easton Lambert syndrome or amyotrophic lateral sclerosis.1

For full information on contraindications, adverse events and precautions, please refer to the Summary of Product Characteristics before use.

Over 100 million treatments delivered worldwide for aesthetics indications to date.Fast-acting and long-lasting, patients saw results as early as 24 hours5-8 and for up to 5 months.5-7,9-12

Azzalure® (Botunlinum toxin type A) is indicated for the temporary improvement in the appearance of glabellar lines (vertical lines between the eyebrows) and lateral canthal lines (crow’s feet lines) in adult patients under 65 years, when severity of these lines has an important psychological impact on the patient.13

Using Azzalure, your patients could experience rapid and long-lasting results, with consistent results seen as early as 24 hours5-8 and a total treatment effect that can last up to 5 months for glabellar lines.5-7,9-12

With over three decades of clinical experience**, Azzalure has a well-established safety profile13 with predictable treatment results help patients feel more attractive and confident.8,12,14,15

The most frequent undesirable reactions observed are headache and injection site reactions for glabellar lines and headache, injection site reactions and eyelid oedema for lateral canthal lines. In general, treatment/injection technique related reactions occurred within the first week following injection and were transient. The incidence of treatment/injection technique related reactions decreased over repeat cycles. Undesirable effects may be related to the active substance, the injection procedure, or a combination of both.13

For full information on contraindications, adverse events and precautions, please refer to the Summary of Product Characteristics before use.

** Compound approved for therapeutic use in December 1990 and aesthetic use in April 2009.

References: 1. Alluzience Summary of Product Characteristics; 2. Hilton S, et al. Dermatol Surg. 2022;48(11):1198-202; 3. Gerber PA, et al. Poster presented at IMCAS World Congress. January 2023. Paris, France. 4. Galderma Data on File MA-52573; 5.  Kassir R et al. Dermatol Ther (Heidelb) 2013;3(2):179–189; 6.  Maas C et al. Aesthet Surg J 2012;32(1 Suppl):S8–S29; 7.  Monheit GD et al. Dermatol Surg 2020;46(1):61–69; 8. Moy R et al. Arch Facial Plast Surg 2009;11(2):77–83; 9. Warren H et al. Plast Surg Nurs 2020;40(1):37–44; 10. Brandt F et al. Dermatol Surg 2009;35(12):1893–1901; 11(2):77–83. 11. Rzany B et al. Dermatol Surg 2007;33(1 Spec No):S18–S25; 12. Gubanova E et al. Aesthet Plast Surg 2018;42(6):1672–1680; 13. Azzalure Summary of Product Characteristics; 14.  Molina B et al. J Eur Acad Dermatol Venereol 2015;29(7):1382–1388; 15. Schlessinger J et al. Dermatol Surg 2021;47:504–509.


Adverse events should be reported. For the UK, Reporting forms and information can be found at or search for Yellow Card in the Google Play or Apple App Store.

For Ireland, Suspected adverse events can be reported via HPRA Pharmacovigilance, Website:; Adverse events should also be reported to Galderma (UK) Ltd,
Email: Tel: +44 (0) 300 3035674

GB-ALZ-2300034 DOP August 2023